Status of diagnostic approaches to AQP4-IgG seronegative NMO and NMO/MS overlap syndromes
نویسندگان
چکیده
منابع مشابه
Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?
While neuromyelitis optica (NMO) immunoglobulin (Ig) G is considered the hallmark serologic marker of NMO, its association is not absolute, as NMO IgG is not detected in approximately one-fourth of the patients diagnosed with NMO spectrum disorder (NMOSD). Thus, the recent discovery that antibodies to myelin oligodendrocyte glycoprotein (MOG) are detected in some NMO IgG-seronegative patients m...
متن کاملSeroprevalence of NMO-IgG Antibody in Neuromyelitis optica (NMO) and Its Specificity in Differentiating NMO from Other Demyelinating Diseases with Overlap Symptoms: An Iranian Experience.
Neuromyelitis optica is an inflammatory demyelinating disease (IDD) of the CNS, which mainly affects optic nerve and spinal cord. Autoantibodies against aquaporin-4 also known as NMO-IgG have been implicated in the pathogenesis of NMO. We evaluated the sensitivity and specificity of NMO-IgG assay for diagnosing NMO patients and differentiating them from MS patients and those with undifferentiat...
متن کاملNeuromyelitis optica spectrum disorders: Comparison according to the phenotype and serostatus.
OBJECTIVE To (1) determine the value of the recently proposed criteria of neuromyelitis optica (NMO) spectrum disorder (NMOSD) that unify patients with NMO and those with limited forms (NMO/LF) with aquaporin-4 immunoglobulin G (AQP4-IgG) antibodies; and (2) investigate the clinical significance of the serologic status in patients with NMO. METHODS This was a retrospective, multicenter study ...
متن کاملseroprevalence of nmo-igg antibody in neuromyelitis optica (nmo) and its specificity in differentiating nmo from other demyelinating diseases with overlap symptoms: an iranian experience.
neuromyelitis optica is an inflammatory demyelinating disease (idd) of the cns, which mainly affects optic nerve and spinal cord. autoantibodies against aquaporin-4 also known as nmo-igg have been implicated in the pathogenesis of nmo. we evaluated the sensitivity and specificity of nmo-igg assay for diagnosing nmo patients and differentiating them from ms patients and those with undifferentiat...
متن کاملWhere Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic necrosis in a complement-dependent manner, additional triggers are also sus...
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ژورنال
عنوان ژورنال: Journal of Neurology
سال: 2015
ISSN: 0340-5354,1432-1459
DOI: 10.1007/s00415-015-7952-8